PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

United States Patent Application 20080161592
Kind Code A1
Blaskovich; Mark Arnold Thomas ; et al. July 3, 2008

Abstract
The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Inventors: Blaskovich; Mark Arnold Thomas; (Bardon, AU) ; Baughman; Ted; (Bothell, WA) ; Little; Thomas; (Redmond, WA) ; Patt; William; (Lawrence, KS) ; Qabar; Maher; (Sammamish, WA) ; Schultz; Lauri Marie; (Batavia, IL) ; Hong; Feng; (Bellevue, WA) ; Nagula; Gangadhar; (Bothell, WA) ; Gage; Jennifer Lynn; (Kenmore, WA) ; Howbert; James Jeffrey; (Bellevue, WA)
Correspondence Name and Address: MERCHANT & GOULD PC
P.O. BOX 2903
MINNEAPOLIS
MN
55402-0903
US

Assignee Name and Adress: CEPTYR, INC.
Bothell
WA

Serial No.: 043872
Series Code: 12
Filed: March 6, 2008

U.S. Current Class: 558/190; 560/32; 560/42; 562/15
U.S. Class at Publication: 558/190; 562/15; 560/32; 560/42
Intern'l Class: C07F 9/22 20060101 C07F009/22; C07F 9/28 20060101 C07F009/28