Review: Whole Grain Intake, CVD, Diabetes

Review: Whole Grain Intake, CVD, Diabetes
12/10/2008
Food Product Design

BETHESDA, Md.—In 2005, cardiovascular disease and diabetes were the first and seventh leading causes of death in the United States, responsible for more than 650,000 and 75,000 deaths, respectively. The U.S. Food and Drug Administration (FDA) has allowed food manufacturers to make health claims linking whole grains consumption to CVD risk reduction since 1999. However, it was not until 2006 that the FDA defined whole grains in its guidance to the industry and to assist manufacturers in labeling their products.

In this guidance document, FDA defined whole grains as the intact, ground, cracked or flaked fruit of the grains whose principal components—the starchy endosperm, germ and bran—are present in the same relative proportions as they exist in the intact grain.

The Kellogg Company requested that the Life Science Research Office, Inc. (LSRO) conduct a third-party, independent evaluation of the effect of strict application of the FDA definition of whole grains on the scientific basis for whole grains health claims. LSRO convened a panel of independent scientists to comprehensively review the relevant scientific literature about whole grains consumption and risks of CVD and diabetes. The Expert Panel's findings and conclusions are presented in the latest LSRO report titled, “Whole Grain Intake and Cardiovascular Disease and Whole Grain Intake and Diabetes: A Review.”

Key findings and conclusions include:

* Using the FDA definition for whole grains as a selection criterion to evaluate the scientific literature is limiting because most of the studies use a broader concept of whole grains.

* The few studies that meet the FDA whole grains definition provide insufficient scientific evidence to support a CVD health claim.

* A whole grains and CVD health claim is supported when a larger number of studies that use a broader concept of whole grain that includes isolated bran, germ or fiber in their analysis of whole grains are also considered.

* The scientific evidence on risk reduction of diabetes and whole grain consumption is suggestive, but not conclusive, whether or not the study meets the FDA definition of whole grains.

This type of analysis is complicated by the diversity in nutrients and bioactive components of different types of whole grains.

* Sources: Life Science Research Office, Inc.: Whole Grain Intake, Cardiovascular Disease and Diabetes: A Review

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