Shared Genetic Risk Factors for Type 1 Diabetes and Celiac Disease

Shared Genetic Risk Factors for Type 1 Diabetes and Celiac Disease
Robert M. Plenge, M.D., Ph.D.
December 25, 2008
Volume 359:2837-283, Number 26

Some families seem to be afflicted with more than their fair share of chronic illness — and sometimes more than one. Why does a particular disease develop in some members of a given family, whereas other members fall victim to apparently unrelated conditions? A simple model is that exposure to environmental risk factors in a genetically susceptible host leads to disease. A particular combination of genetic and environmental risk factors (together with chance and bad luck) leads to one disease, and another combination of factors leads to a different disease. Because members of the same family have exposure to many . . .

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