A spoonful of sugar is sufficient for diabetic atherosclerosis
A spoonful of sugar is sufficient for diabetic atherosclerosis
medicalnewstoday.com
Main Category: Diabetes
Article Date: 27 Aug 2005 - 1:00 PST.
People with diabetes are more likely to develop atherosclerosis, leading to more heart attacks and strokes in this population. But evidence that hyperglycemia in these patients contributes to atherosclerosis was lacking. In a study appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Ira Goldberg and colleagues from Columbia University show that hyperglycemia alone can accelerate atherosclerosis.
The researchers create mice lacking a gene called aldose reductase (AR) that mediates the generation of toxic products from glucose and cross these mice with atherosclerosis-prone mice lacking a protein called Ldlr. They found that AR expression modulates atherosclerosis development in the diabetic animals. Thus, inhibitors of AR or other proteins that mediate glucose toxicity may be useful for treating diabetic atherosclerosis.
TITLE:Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice
AUTHO: Ira J. Goldberg Columbia University, New York, NY USA
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