An Overview of Glyburide Drug Interactions

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An Overview of Glyburide Drug Interactions

If other medications are taken with glyburide, drug interactions are possible. For example, a combination of glyburide with beta blockers, certain decongestants, and oral contraceptives can cause the body to metabolize the medications differently than intended and increase the risk of low blood sugar or make glyburide less effective. If glyburide drug interactions are a concern, your healthcare provider may adjust your dosages.

Glynase®, or Micronase®) can potentially interact with other medications. Some of the drugs that may lead to glyburide druinteractions include:

Beta blockers, such as:

Atenolol (Tenormin®)
Bisoprolol (Zebeta®)
Metoprolol (Lopressor®, Toprol XL®)
Nadolol (Corgard®)
Propranolol (Inderal®)
Sotalol (Betapace®)
Timolol (Blocadren)
Carvedilol (Coreg®)
Labetalol (Trandate®).

Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)

Corticosteroids, such as:

Betamethasone (Celestone®)
Cortisone
Dexamethasone (Decadron®)
Fludrocortisone (Florinef®)
Hydrocortisone (Cortef®)
Methylprednisolone (Depo-Medrol®, Medrol®)
Prednisolone (Ovapred®, Pediapred®)
Prednisone
Triamcinolone (Kenalog®, Aristospan®).

Diuretics, such as:

Acetazolamide (Diamox®)
Amiloride (Midamor®)
Bumetanide (Bumex®)
Chlorothiazide (Diuril®)
Chlorthalodone
Ethacrynic acid (Edecrin®)
Furosemide (Lasix®)
Hydrochlorothiazide (Microzide®, HCTZ)
Metolazone (Zaroxolyn®)
Torsemide (Demadex®)
Triamterene (Dyrenium®, Dyazide®, Maxzide®).

Estrogens

Fluoroquinolone antiobiotics, including:

Ciprofloxacin (Cipro®)
Gatifloxacin (Tequin®)
Levofloxacin (Levaquin®)
Moxifloxacin (Avelox®)
Norfloxacin (Noroxin®)
Ofloxacin (Floxin®).

Isoniazid

Monoamine oxidase inhibitors (MAOIs), including:

Isocarboxazid (Marplan®)
Phenelzine (Nardil®)
Rasagiline (Azilect®)
Selegiline (Eldepryl®, Emsam®, Zelapar®)
Tranylcypromine (Parnate®).

Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

Ibuprofen (Motrin®, Advil®)
Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
Diclofenac (Cataflam®, Voltaren®)
Indomethacin (Indocin®)
Nabumetone (Relafen®)
Oxaprozin (Daypro®)
Celecoxib (Celebrex®)
Meloxicam (Mobic®)
Etodolac (Lodine®)
Ketoprofen (Orudis®)
Ketorolac (Toradol®).

Oral contraceptives (birth control pills)

Phenothiazine medications, including:

Chlorpromazine
Fluphenazine (Prolixin®)
Perphenazine
Promethazine (Phenergan®)
Thioridazine (Mellaril®)
Trifluoperazine.

Phenytoin (Dilantin®)

Probenecid (Benuryl®, ColBenemid®)

Salicylates, such as:

Aspirin
Choline magnesium trisalicylate (Trilisate®)
Diflunisal (Dolobid®)
Salsalate (Salflex®, Disalcid®, Amigesic®).

Sulfonamides ("sulfa drugs"), including:

Sulfadiazine
Sulfadoxine (Fansidar®)
Sulfamethoxazole (Bactrim®, Septra®)
Sulfisoxazole (Gantrisin®).

Thyroid medications, such as:

Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®)
Liothryonine (Cytomel®)
Thyroid (Armour Thyroid®)
Thyrolar®.

Warfarin (Coumadin®, Jantoven®).

Glyburide Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when glyburide is combined with any of the medications listed above.

Beta Blockers
Taking glyburide with beta blockers can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a beta blocker.

Certain Decongestants
If glyburide is taken with certain decongestants, this can make glyburide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping decongestants, to prevent this interaction from occurring.

Corticosteroids
If glyburide and corticosteroids are taken together, this can make glyburide less effective, which may increase your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a corticosteroid.

Diuretics
Combining glyburide with diuretics can make glyburide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a diuretic.

Estrogens
If glyburide and estrogens are combined, this can make glyburide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping an estrogen.

Fluoroquinolone Antibiotics
Taking glyburide with fluoroquinolones can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a fluoroquinolone, depending on your particular situation.

Isoniazid
If glyburide and isoniazid are taken together, this can make glyburide less effective, which may increase your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping isoniazid.

Monoamine Oxidase Inhibitors
Taking glyburide with MAOIs can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping an MAOI.

Niacin
If glyburide is taken with niacin, this can make glyburide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping niacin.

Nonsteroidal Anti-Inflammatory Drugs
Taking glyburide and NSAIDs together can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when stopping or starting an NSAID, depending on your particular situation.

Oral Contraceptives
Combining glyburide with oral contraceptives (birth control pills) can make glyburide less effective, possibly increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping an oral contraceptive.

Phenothiazines
If glyburide is combined with phenothiazines, this can make glyburide less effective, which may increase your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a phenothiazine, to prevent this interaction from occurring.

Phenytoin
Taking glyburide and phenytoin together can make glyburide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping phenytoin.

Probenecid
Taking glyburide with probenecid can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping probenecid.

Salicylates
If glyburide and salicylates are combined, this can increase your risk of low blood sugar (hypoglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a salicylate.

Sulfonamides
Taking glyburide and sulfonamides together can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a sulfonamide, depending on your particular situation.

Thyroid Medications
If glyburide and thyroid medications are combined, this can make glyburide less effective, which may increase your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide dose, especially when starting or stopping a thyroid medication, to prevent this interaction from occurring.

Warfarin
Glyburide may interact with wafarin, although the full effects of this interaction are not known. Your may need to be monitored more frequently (and your warfarin dose may need to be adjusted) when starting or stopping glyburide.