Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients - Clinical Trials for Diabetic Dental Problems

Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients
ClinicalTrials.gov

This study is currently recruiting participants.
Verified by University Hospital, Strasbourg, France, January 2009

Sponsored by: University Hospital, Strasbourg, France
Information provided by: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00399620

Purpose

Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone.

This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations. Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.

Condition: Periodontitis and Diabetitis
Procedure: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).

Study Type: Interventional
Study Design: Diagnostic, Non-Randomized, Open Label, Single Group Assignment, Uncontrolled
Official Title: Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis

Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 90
Study Start Date: March 2008

Eligibility

Ages Eligible for Study: 20 Years to 80 Years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: Yes
Criteria

Inclusion criteria:

* Patients from 20 to 80 years old
* A minimum of 10 teeth
* Healthy volunteers or diabetic patients with or without periodontitis

Exclusion criteria:

* a course of antibiotics
* a fungicidal therapy
* a corticotherapy
* a hormone therapy
* a pregnancy
* persons under guardianship

Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00399620

Contact: Martine Soell, MD
33 6 74 86 67 36
Locations: France
Département de Parodontologie - Hôpital Civil
Strasbourg, France, 67091
Principal Investigator: Martine Soell, MD
Sub-Investigator: Frédéric Blickle, MD
Sponsors and Collaborators: University Hospital, Strasbourg, France
Study Director: Martine Soell, MD (Hôpitaux Universitaires de Strasbourg)

ClinicalTrials.gov processed this record on March 06, 2009