Oral therapies for diabetic hyperglycemia - Diabetic Hyperglycemia Drugs and Medications

Oral therapies for diabetic hyperglycemia
2001
LEBOVITZ Harold E. (1)
CAT.INIST

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Medicine, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, ETATS-UNIS
Résumé / Abstract
Many classes of oral antihyperglycemic agents are available for the treatment of type 2 diabetic patients. These classes improve glucose metabolism by different mechanisms, and their effects are additive. Therapy with lifestyle modification and a single oral antihyperglycemic agent infrequently achieves target glycemic goals, and if it does, the effect usually is not sustained. A more rational approach is therapy and a combination of drugs with different mechanisms of action. Initial therapy might be with submaximal concentration of two drugs. As the diabetic abnormalities progress, maximal concentrations of the drugs and addition of other classes of oral agents or insulin may be needed to maintain the target glycemic goal. In choosing combinations of oral antihyperglycemic agents, their effects on the components of the insulin resistance syndrome, their side-effect profiles, and the specific effects of the agents on glucose metabolism must be considered.

Revue / Journal Title
Endocrinology and metabolism clinics of North America ISSN 0889-8529 CODEN ECNAER

Source / Source
2001, vol. 30, no 4 (258 p.) (73 ref.), [Note(s) : vii,909-933 [26 p.]]

Langue / Language
Anglais

Editeur / Publisher
Elsevier, Philadelphia, PA, ETATS-UNIS (1987) (Revue)

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