Symlin Drug Interactions - Symlin (Pramlintide) Drug Interactions

Symlin Drug Interactions
eMedTV.com

Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;

Symlin drug interactions with other medications, such as pain medications, acarbose, and anticholinergic medications, can increase your risk of side effects. Because the drug can slow down the movement of medications through the digestive tract, it can delay the onset of side effects due to other medications. To prevent drug interactions with Symlin, you may need to take other medicines an hour before or two hours after you take it.

An Overview of Symlin Drug Interactions
Symlin? (pramlintide acetate) can potentially interact with several medicines. Some of the medicines that may lead to Symlin drug interactions include:

* Acarbose (Precose?)
* Miglitol (Glyset?)
* Pain medications
* Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal?, B&O Supprettes?, Bellamine S?)
o Benztropine (Cogentin?)
o Clidinium (Librax?)
o Clozapine (Clozaril?)
o Darifenacin (Enablex?)
o Dicyclomine (Bentyl?)
o Diphenhydramine (Benadryl?, Tylenol PM?)
o Glycopyrrolate (Robinul?)
o Haloperidol (Haldol?)
o Homatropine (Hycodan?)
o Hyoscyamine (Levsin?)
o Ipratropium (Atrovent?)
o Scopolamine (Transderm Scop?)
o Tiotropium (Spiriva?)
o Tolterodine (Detrol?)
o Trospium (Sanctura?).

Symlin Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when Symlin is taken with any of the drugs listed above.

Acarbose
Taking Symlin with acarbose may increase your risk of side effects affecting the digestive tract. It is not recommended that these two medications be taken together.

Miglitol
Combining Symlin with miglitol may increase your risk of side effects affecting the digestive tract. It is not recommended that these two medications be taken together.

Pain Medications
Because Symlin slows down the digestive tract, it can also delay the onset of other side effects due to other medications, including pain medications. If you desire rapid pain relief, make sure to take your pain medication at least one hour before, or two hours after, your Symlin dosage, if possible.

Anticholinergics
Anticholinergics and Symlin can both slow down the action of the digestive tract, and taking Symlin with anticholinergic medications may increase your risk of side effects (especially nausea or vomiting). It is not recommended that Symlin be taken with anticholinergic medications.

Final Thoughts on Symlin Drug Interactions
It is possible that not all Symlin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.

E-mail: clinaero@clinaero.com
Phone: 425.452.1344
Fax: 425.452.1345
Copyright © 2006-2008 Clinaero, Inc.