Coffee and caffeine may improve bladder dysfunction in ...

Coffee and caffeine may improve bladder dysfunction in diabetes by raising cAMP content

Coffee and caffeine may improve bladder dysfunction in diabetes by raising cAMP content

NewsRx.com

09-27-06

Coffee and caffeine may improve bladder dysfunction in diabetes by raising cyclic AMP content in lower urinary tract.

Researchers in People's Republic of China conducted a study "to explore the effects and mechanisms of caffeine and coffee on bladder dysfunction in streptozotocin-induced diabetic rats."

"Sprague-Dawley male rats were divided randomly into 4 groups: control, diabetes mellitus (DM), DM with coffee treatment, and DM with caffeine treatment. The diabetic rat was induced by intraperitoneal injection of streptozotocin (60 mg/kg).After 7 weeks of treatment with coffee and caffeine, cystometrogram, contractile responses to electrical field stimulation (EFS) and acetylcholine (ACh), and cyclic AMP (cAMP) concentration of the bladder body and base were measured," wrote C.R. Yi and colleagues, Nanjing University.

The scientists found, "The bladder weight, volume threshold for micturition and postvoid residual volume (PVR) in the diabetic rats were significantly higher compared to those in the control animals. Coffee or caffeine treatment significantly reduced the bladder weight, bladder capacity and PVR in the diabetic rats. DM caused significant decreases in cAMP concentration of the bladder and coffee and caffeine caused upregulation of c AMP content in the diabetic bladder."

"In addition," continued investigators, "coffee and caffeine tended to normalize the altered detrusor contractile responses to EFS and ACh in the diabetic rats."

The researchers concluded, "These results indicate that caffeine and coffee may have beneficial effects on bladder dysfunction in the early stage of diabetes by increasing cAMP content in the lower urinary tract, recovering the micturition reflex and improving the detrusor contractility."

Yi and colleagues published the results of their research in Acta Pharmacologica Sinica (Effects of coffee and caffeine on bladder dysfunction in streptozotocin-induced diabetic rats. Acta Pharmacol Sin, 2006;27(8):1037-1043).

For additional information, contact C.R. Yi, Nanjing University, School Medical, Affiliated Drum Tower Hospital, Dept. of Urology, Nanjing 210008, People's Republic of China.

The publisher of the journal Acta Pharmacologica Sinica can be contacted at: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England.

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