Comment on Prevention of Diabetic Atherosclerosis
Comment on Prevention of Diabetic Atherosclerosis
pediatrics.aappublications.org
PEDIATRICS Vol. 54 No. 4 October 1974, pp. 522
William M. Hicks M.D.
The prevention of diabetic atherosclerosis may not be as easy as exerting good control over one's diabetes.1 Preliminary studies of the activity of pyrophosphatase in bone cells show that pre-incubation with human insulin in physiologic concentrations resulted in a three-fold increase in the activity of pyrophosphatase. Pyrophosphates (P-Pi) are liberated in the process of breaking high energy phosphate bonds. P-Pi are in the serum and in the aorta in concentrations large enough to prevent or inhibit calcification.2
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