Glipizide (Glucotrol) - drug class, medical uses, medication side effects and drug interactions

Glipizide (Glucotrol) - drug class, medical uses, medication side effects and drug interactions
Jay W. Marks, MD, Medical and Pharmacy Editor
MedicineNet.com

DRUG INTERACTIONS: Alcohol may prolong the action of glipizide by delaying the absorption and elimination of glipizide. Patients taking glipizide should keep alcohol consumption to a minimum. Cholestyramine may reduce the absorption and consequently the effect of glipizide. Therefore, glipizide should be administered 1-2 hours before cholestyramine is administered. Fluconazole (Diflucan) may increase the absorption and therefore increase the effect of glipizide.

Many drugs can potentially increase or decrease glucose levels thus increasing or decreasing the effect of glipizide. Drug interactions which cause low blood glucose (hypoglycemia) can occur with nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), sulfa drugs, warfarin, miconazole, and beta-blockers (e.g., propranolol). Drug interactions which cause high blood glucose (hyperglycemia) can occur with thiazide diuretics, corticosteroids, thyroid medicines, estrogens, niacin, phenytoin, and calcium channel blocking drugs (e.g., diltiazem). Patients should be monitored closely for loss of glucose control when such drugs are administered.

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