Indoles having anti-diabetic activity
Indoles having anti-diabetic activity
United States Patent 7,393,960
Acton, III , et al. July 1, 2008
Abstract
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
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Inventors: Acton, III; John J. (Cranford, NJ), Meinke; Peter T. (Plainfield, NJ), Wood; Harold B. (Westfield, NJ), Black; Regina M. (Cranford, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Appl. No.: 10/525,470
Filed: August 28, 2003
PCT Filed: August 28, 2003
PCT No.: PCT/US03/26679
371(c)(1),(2),(4) Date: February 24, 2005
PCT Pub. No.: WO2004/019869
PCT Pub. Date: March 11, 2004
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Related U.S. Patent Documents
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Application Number Filing Date Patent Number Issue Date
60440741 Jan., 2003
60406737 Aug., 2002
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Current U.S. Class: 548/241
Current International Class: C07D 261/20 (20060101); A01N 43/80 (20060101)
