Type 1 Diabetes Symptoms, Diagnosis, & Treatments of Ty...

Type 1 Diabetes Symptoms, Diagnosis, & Treatments of Type 1 Diabetes

Type 1 Diabetes Symptoms, Diagnosis, & Treatments of Type 1 Diabetes
Type 1 Diabetes is much less common than Type 2 Diabetes and typically affects younger individuals. Type 1 Diabetes usually begins before age 40 although there are exceptions. In the United States, the peak age at diagnosis is around 14. Type 1 Diabetes is associated with deficiency (or lack) of insulin. It is not known why, but the pancreatic islet cells quit producing insulin in the quantities needed to maintain a normal blood glucose level. Without sufficient insulin, the blood glucose rises to levels which can cause some of the common symptoms of hyperglycemia. These individuals seek medical help when these symptoms arise, but they often will experience weight loss developing over several days associated with the onset of their diabetes. The onset of these first symptoms may be fairly abrupt or more gradual.

Incidence of Type 1 Diabetes
Type 1 DiabetesIt has been estimated that the yearly incidence of Type 1 diabetes developing is 3.7 to 20 per 100,000. More than 700,000 Americans have this type of diabetes. This is about 10 percent of all Americans diagnosed with diabetes...the other 90 percent have Type 2 Diabetes.

Causes of Type 1 Diabetes
Islet cells of the pancreas.Type 1 DiabetesType 1 Diabetes usually develops due to an autoimmune disorder. This is when the body's immune system behaves inappropriately and starts seeing one of it's own tissues as foreign. In the case of Type 1 Diabetes, the islet cells of the pancreas that produce insulin are seen as the "enemy" by mistake. The body then creates antibodies to fight the "foreign" tissue and destroys the islet cells ability to produce insulin. The lack of sufficient insulin thereby results in diabetes. It is unknown why this autoimmune diabetes develops. Most often it is a genetic tendency. Sometimes it follows a viral infection such as mumps, rubella, cytomegalovirus, measles, influenza, encephalitis, polio or Epstein-Barr virus. Certain people are more genetically prone to this happening although why this occurs is not know. Thus, two people may be infected with the same virus and only one of them who is genetically prone will go on to develop diabetes. Other less common ( very rare) causes of Type 1 Diabetes include injury to the pancreas from toxins, trauma, or after the surgical removal of the majority (or all) of the pancreas.

Herititary Tendencies in Type 1 Diabetes
Type 1 DiabetesType 1 Diabetes tends to have less tendency to have other family members affected with diabetes than Type 2. In the first large family study of diabetes, less than 4% of parents and 6% of siblings of a person with diabetes also had diabetes. In studies with identical twins less than 50% of the siblings of a person with diabetes also had diabetes versus almost 100% of siblings of people with Type 2 Diabetes. Children of Type 1 diabetic fathers are more likely to develop Type 1 autoimmune diabetes than children of Type 1 diabetic mothers.

Treatment of Type 1 Diabetes
Type 1 DiabetesType 1 Diabetes must be treated with insulin shots. This involves injecting insulin under the skin -- in the fat -- for it to get absorbed into the blood stream where it can then access all the cells of the body which require it. Insulin cannot be taken as a pill because the juices in the stomach would destroy the insulin before it could work. Remember, insulin is a hormone, and like all other hormones, insulin is a protein and therefore it has a very important 3-dimentional structure which is destroyed by the acid in the stomach. Even if it did make it through the stomach, the digestive enzymes secreted by the digestive part of the pancreas would digest the insulin protein molecule. Scientists are looking for new ways to give insulin. But today, shots are the most widely used method. Some new insulin pumps are being developed and tested.

Endocrine Web